NFL Week 10 Picks: Bills, 49ers and Raiders Against the Spread
Gardner Minshew’s run in Arizona ended faster than anyone expected, and so did our shot at another perfect week. We came agonizingly close to the backdoor cover we wanted. Then Minshew’s elbow gave out, and the Cardinals had no way back. Still, we finished 2-1 and banked another winning week.
So we roll straight on to our NFL Week 10 picks. We like three sides on Sunday, November 15, and two of them are road favorites. Here’s what we’re playing and why.
Our NFL Week 10 Picks at a Glance
All three of our NFL Week 10 picks kick off on Sunday afternoon. First up is Buffalo in New Jersey at 1pm ET. After that, the late window brings Seattle at Las Vegas and San Francisco at Dallas. The table below lists each line we took, plus kickoff times and stadiums.
| Our Pick | Matchup | Kickoff (ET) | Stadium |
|---|---|---|---|
| Bills -7.5 | Buffalo Bills at New York Jets | 1:00pm | MetLife Stadium |
| 49ers -4 | San Francisco 49ers at Dallas Cowboys | 4:25pm | AT&T Stadium |
| Raiders +6.5 | Seattle Seahawks at Las Vegas Raiders | 4:05pm | Allegiant Stadium |
All games Sunday, November 15, 2026. Lines shown are the numbers we took, so check the current price before you bet.
Bills -7.5 at Jets: Riding Josh Allen Again
We’re riding Josh Allen and the Bills again this week. Buffalo visits MetLife Stadium, and we expect a double-digit win. The Bills suddenly have Jacksonville pushing them in the race for the AFC’s top seed. As a result, there’s no room to coast against a division rival.
The market agrees with us, too. According to RotoWire’s Week 10 line moves, this spread opened at Bills -7 and has since climbed to -8.5. Roughly four in five tickets sit on Buffalo. We grabbed -7.5, and we look for the Bills to cover and win big on the road.
49ers -4 at Cowboys: Another Road Favorite We Trust
Yes, it’s another road favorite. San Francisco heads to AT&T Stadium for the 4:25pm ET kickoff, fresh off a 38-17 thrashing of the Raiders. Dallas, on the other hand, has been hot garbage.
Put this game in Santa Clara and the number would sit closer to 49ers -6.5. That gap tells you how little respect the Cowboys have earned. Meanwhile, Dallas tight end Jake Ferguson carries a knee injury into the week. This line also swung hard, opening at Cowboys -1.5 before moving to San Francisco. We like the 49ers to win by a touchdown here.
Raiders +6.5 vs Seahawks: Fernando Mendoza Takes Over
It’s a new era in Vegas. The Raiders traded Kirk Cousins to Minnesota, so No. 1 overall pick Fernando Mendoza makes his first NFL start at Allegiant Stadium. Kickoff is 4:05pm ET on CBS. Before this, his only regular season action came against New England, where he went 6 of 8 for 48 yards.
Better still for Las Vegas, the Seahawks arrive beat up. Sam Darnold is out with quad and rib injuries, so Drew Lock gets the start while managing elbow and oblique issues of his own. Guard Quenton Nelson is out as well after a minor knee procedure.
Will the Raiders win in Mendoza’s much anticipated debut? No. However, they’ll keep it close for him until a late Jason Myers field goal does them in. Books have dealt this one anywhere from Seattle -3.5 to -6.5, so shop around. We’re on Raiders +6.5 and wouldn’t chase it much lower.
How to Bet Our NFL Week 10 Picks
That’s three sides, two road favorites and one rookie quarterback with a home crowd behind him. All of our NFL Week 10 picks land on Sunday, November 15, so there’s plenty of time to lock them in before the 1pm ET start in New Jersey. If you’re watching at a Winners venue in Connecticut, sports betting there runs through Fanatics Sportsbook.
So there you have it. On to another profitable week, hopefully 3-0, with Vic’s Picks and MyWinners.
Go here to find your nearest MyWinners or Winners venue in CT.
